TNNT2 and myocardial infarction: For instance, current assays exhibit low sensitivity in detecting critical miRNAs such as miR-208a and miR-499 in acute myocardial infarction (MI) patients (Crouser et al., 2021), and cTnT fails to diagnose unstable angina due to its reliance on irreversible myocardial necrosis (Kuwabara et al., 2011).