Altogether, our findings suggest that CD73 is involved in the early phases of sepsis as a neuroprotective factor, owing to the massive production of adenosine, which acts as a modulatory, immunosuppressive, anti-inflammatory, and protective agent (Haskó et al., 2011; Ledderose et al., 2016; Zhang T. et al., 2022). This evidence concerns the gene NT5E and Sepsis.