The heightened oxidative stress observed in SCD penile tissue is linked with an upregulation of NOX-2 NADPH oxidase expression and the uncoupling of eNOS (Musicki et al., 2011; Musicki et al., 2014; Bivalacqua et al., 2013; Silva et al., 2016b; Pereira et al., 2022). The gene discussed is NOS3; the disease is Schnyder corneal dystrophy.