Members of the BDNF signaling pathway such as TrkB, AKT, ERK, and CREB play critical roles in the pathophysiology of depression (Gong et al., 2024; Qin et al., 2024; Mohammadi et al., 2023; Matin and Dadkhah, 2024). The gene discussed is BDNF; the disease is major depressive disorder.