TP53 and breast cancer: In preclinical studies of other research groups, resveratrol has been reported to decrease H4R3me2s and H3K27me3 levels while increasing H3K9ac and H3K27ac levels in MCF-7 and MDA-MB-231 BC cell lines, effects linked to its cytotoxic activity and upregulation of tumor suppressor genes, including BRCA1, p53, and p21 (Chatterjee et al., 2019).