Wenjie Chen et al. developed a dual pH-responsive hydrogel cross-linked with a tumor acidity neutralizer (mesoporous bioactive glass nanoparticles) and a NET lyase (deoxyribonuclease I, DNase I), and used it in combination with NK infusion to prevent postoperative tumor recurrence (Figure 7) (Cheng et al., 2022). This evidence concerns the gene DNASE1 and neoplasm.