Nrf2 is also able to modulate the mRNA stability of STING to regulate STING, Nrf2 also regulates STING expression by modulating STING mRNA stability (Olagnier et al., 2018), and the cGAS-STING signaling pathway plays a key role in renal inflammation and fibrosis, and inhibition of cGAS-STING signaling attenuates renal inflammation and fibrosis in a model of unilateral ureteral obstruction (Jiao et al., 2025). This evidence concerns the gene CGAS and Ureteral obstruction.