NFE2L2 and diabetic kidney disease: To verify the effect of 5-HT on diabetic nephropathy and the relationship between 5-HT and the Nrf2 pathway, we administered sarpogrelate hydrochloride to inhibit 5-HT in HK-2 cells, which were stimulated with HG combined with 500 μg/mL HKC for coadministration therapy.