GPT and Decreased total neutrophil count: The most common all-grade adverse events were diarrhea (62%), constipation (44%), and nausea (42%) in abemaciclib plus anastrozole (15), while the most common grade 3–4 AEs in ribociclib plus letrozole were neutropenia (43%) and elevated alanine aminotransferase concentrations (20%) (38).