CRIF1 (also known as MRPL64), recruited to the promoter region of the p53 gene, was initially identified as an interacting protein of Gadd45γ and can inhibit cell growth and tumor formation by interacting with p53 and Gadd45 family proteins, and was also found to be associated with good prognosis in colorectal cancer, suggesting its potential as a tumor suppresso (65). This evidence concerns the gene GADD45A and neoplasm.