In renal cancer, MRPL41, stabilizing p53, is downregulated in cancer cell lines compared to pre-cancerous cell lines and promotes its translocation to the mitochondria, inducing apoptosis., and leading to cell cycle arrest at the G1 phase in the absence of p53 (62), which suggests that MRPL41 downregulation may contribute to renal cancer progression. The gene discussed is TP53; the disease is renal carcinoma.