Bioinformatics analysis has revealed that the rs4919510 variant G allele in miR-608 is associated with high expression of MRPL43, and knockdown of the MRPL43 gene effectively inhibits the proliferation, invasion, and migration capabilities of the colorectal cancer HCT-116 cell line and promotes apoptosis (66), suggesting that the rs4919510 variant G allele in miR-608 may influence the occurrence and progression of colorectal cancer by upregulating the expression of MRPL43. The absence of the long isoform of MRPL33 (MRPL33-L) results in impaired cell proliferation and increased apoptosis. This evidence concerns the gene MRPL43 and colorectal cancer.