AKT1 and central nervous system cancer: Additionally, silencing MRPS16 significantly reduces the expression levels of proteins such as Snail, p-AKT, and p-PI3K in U-138MG and U-87MG cells (19), further indicating that MRPS16 promotes glioma cell proliferation and invasion through the PI3K/AKT/Snail signaling axis (Figure 4).