SERPINE1 and periodontal disorder: Adipose tissue secretes a biologically active substance called ‘adipocytokine’, which may be potentially harmful to periodontal tissues and that plasminogen activator inhibitor-1 expressed in visceral fat induces visceral blood coagulation and increases the risk of ischaemic vascular disease, which may also reduce blood flow to the periodontium in obese individuals, and promote periodontal disease(53).