DACH1 and colorectal carcinoma: In this study, we combined bioinformatics analyses with clinical sample validation to elucidate the expression trends of DACH1 levels, DACH1 promoter methylation, and DNMT1 levels across different stages of CRC progression and our findings revealed that DNMT1-mediated epigenetic silencing of DACH1 plays a pivotal role in driving CRC initiation and progression.