These findings suggest that LMC KATP channels can potentially be targeted therapeutically by GLIB to improve lymphatic contractile function in animal models of chronic metabolic stress, e.g., db/db, diet-induced obesity, and ApoE-KO among others, as well as in mice displaying a gain of function in KATP channels, as happens in Cantú syndrome patients. The gene discussed is APOE; the disease is obesity due to melanocortin 4 receptor deficiency.