Currently, PtN4C SANzyme has been introduced to remove ROS under tumor microenvironment (TME)-stimulated situations, such as GSH dearth and intracellular H2O2 build-up.48 The SANzyme displayed SOD- and POD-mimicking properties with the conversion of O2 ̇− into H2O2 and ·OH production, respectively. The gene discussed is SOD1; the disease is neoplasm.