Expanding beyond Cushing’s disease, which is caused by ACTH-secreting adenoma, research on Cushing’s syndrome, a disorder resulting from chronic hypercortisolism of either endogenous or exogenous, origin has revealed similar but sometimes more pronounced cognitive impairments, particularly in cases of adrenal-origin hypercortisolism, where ACTH feedback regulation is absent and systemic cortisol levels remain uncontrolled​ (94). This evidence concerns the gene POMC and Cognitive impairment.