Similarly, in the CABLE database, we observed a negative association between the LDL/HDL ratio and the levels of Tau protein and pTau protein in older adults aged over 60, women, participants carrying the APOEε4 gene, participants without diabetes, and participants without hypercholesterolemia, which is consistent with the findings from the ADNI (Supplementary Table 6). Here, MAPT is linked to Hypercholesterolemia.