In our earlier studies on Parkinson’s disease (Henriques et al., 2022), we demonstrated that alpha-synuclein (αSyn) injected in Substantia nigra pars compacta (SNpc), combined with low-level impairments in lysosomal clearance, provides the spark that triggers a growing neurodegenerative fire in the aging brain. This evidence concerns the gene SNCA and Parkinson disease.