ACE2 and infection: Since SARS-CoV-2 replicates primarily in epithelial cells of the upper respiratory tract epithelial cells that express these carbohydrate antigens and also use ACE2 as a receptor, our working hypothesis was to verify that the presence of natural anti-carbohydrate antibodies, including anti-blood group A and B antibodies, could confer a certain level of innate protection against infection by SARS-CoV-2 and can explain the association between ABO phenotype and the severity of infection by SARS-Cov2.