According to earlier research, NSCLC cells enhance their resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) by promoting M2-TAM polarization and inhibiting M1-TAM polarization through the transfer of exosomes to TAM by targeting the miR-627-3p/Smads signaling pathway (83). This evidence concerns the gene EGFR and non-small cell lung carcinoma.