Increased concentrations of PEVs [436 (83.13–1,096) vs. 142 (18.7–1,096), p = 0.007], LEVs [41.1 (0–461.3) vs. 17.4 (0.8–298.4), p = 0.03] and ICAM1 + EVs [16.1 (2.13–175.0) vs. 3.5 (0.6–359.0), p = 0.012] were found in SSc-ILD patients with respiratory symptoms compared to asymptomatic. Here, ICAM1 is linked to interstitial lung disease.