Upregulation of RGPD6, RGPD5, RGPD8, RGPD2, NUP210L, and PLCL1 has been observed in invasive tumors, implicating this functional network in the remodeling of ECM stiffness and integrin signaling, both of which enhance cancer cell migration (14). The gene discussed is RGPD2; the disease is cancer.