Given the potential role of VDR and VDBP gene polymorphisms in the pathogenesis of sepsis, an in-depth exploration of the relationship between these gene polymorphisms and sepsis susceptibility and prognosis not only helps to elucidate the genetic susceptibility mechanisms of sepsis but may also provide new molecular targets for the early diagnosis, risk assessment, and personalized treatment of sepsis. Here, VDR is linked to Sepsis.