The polymorphisms of VDR and VDBP genes and vitamin D genes Fok I (rs2228570) and VDBP rs4588 locus were tested and compared in both groups; and the receiver operating characteristic (ROC) curves were plotted to calculate the area under the area under the curve (AUC) and assess the diagnostic value of each indicator for sepsis. The gene discussed is VDR; the disease is Sepsis.