CSF3 and cancer: Concomitantly, the expression of interleukin-6, interleukin-1 β, tumor necrosis factor α, and target genes of granulocyte colony-stimulating factor, NFkB, and AP-1 was found to be markedly diminished in experiments employing nuclear input inhibition of KPNB1. KPNB1 has been shown to suppress these transcription factors’ activities, making cancer cells more invasive (Stelma and Leaner, 2017).