SUCO and Alzheimer disease: Recent studies demonstrate that cBF subregions (e.g., Ch1/2 and Ch4) exhibit distinct cognitive associations: Ch1/2 atrophy correlates with episodic memory deficits in preclinical AD (Scheef et al., 2019), while Ch4 degeneration predicts attention and visuospatial decline in MCI and synucleinopathies (Brueggen et al., 2015; Rémillard-Pelchat et al., 2022), highlighting its domain-specific role beyond hippocampal memory circuits.