Such T2-mediated downregulation of TSLP release could potentially delay or reduce the severity of virus-induced exacerbations in asthma patients, but on the other hand, the simultaneous decrease in IFNλ1, a key antiviral cytokine in epithelial immunity, may impair the airway's ability to mount an effective defense against viral infections. The gene discussed is IFNL1; the disease is viral infectious disease.