Hartsfield-Bixler-Demyer Syndrome, also known as fibroblast growth factor 1 (FGFR1)-related Hartsfield Syndrome, is a rare genetic disorder characterized by a combination of holoprosencephaly and ectrodactyly spectrum disorder, as well as facial anomalies including cleft lip and palate [1]. The gene discussed is FGFR1; the disease is Hartsfield-Bixler-Demyer syndrome.