VEGFA and neoplasm: Whereas low doses of ionizing radiation promote angiogenesis via the overexpression of VEGF (53), increasing evidence indicates that high doses of hypofractionated irradiation, commonly used in stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS), induce secondary cell death through vascular damage occurring days after irradiation, in addition to direct tumor cell death caused by DNA damage (51).