This properdin deficiency results in low levels of IL-1b mRNA and higher levels of arginase-1, monocyte chemotactic protein-1 (MCP-1), and IL-10 mRNAs, suggesting that a properdin-deficient tumor microenvironment may induce a profile of M2 macrophages with pro-tumoral activity (92). This evidence concerns the gene CCL2 and neoplasm.