Similarly, FH and its isoform FHL-1 expression is specifically induced during cutaneous carcinogenesis (cSCC) and exert effects on intracellular pathways, being negatively regulated by the inhibition of ERK1/2, p38, and MAPK pathways, while being upregulated by IFNγ, IL-1b, TGF-α, TGF-β, and TNF-α. The gene discussed is TGFA; the disease is skin squamous cell carcinoma.