Increased amounts of C7 protein in the nuclei of hepatocellular carcinoma cell lines promotes in vivo cell growth, by upregulating late SV40 factor (LSF-1) protein levels and the expression of stemness factors such as POU Class 5 Homeobox 1, SRY-Box Transcription Factor 2, and MYC Proto-Oncogene Transcription Factor (encoded by OCT4, SOX2, and MYC, respectively) (74). Here, POU5F1 is linked to hepatocellular carcinoma.