On the contrary, TME-driven tumor suppression would include C1q-mediated phosphorylation of the WWOX tumor suppressor, Properdin-dependent activation of the TES-DDIT3 tumor suppressor pathway, CD4+/CD8+ T-cell infiltration due to high intratumoral C3 expression and C3-mediated inhibition of HER2 oncogene expression. The gene discussed is CD8A; the disease is neoplasm.