Mediators that are first secreted by the primary tumor and then by activated resident cells and recruited immune cells (e.g., prostaglandins, nitric oxide, MMPs, VEGF) enhance vascular permeability and angiogenesis, which is critical for the adhesion and extravasation of bone-marrow derived cells into the remote tissue, and create a pro-tumoral and immunosuppressive microenvironment (11). The gene discussed is VEGFA; the disease is neoplasm.