TGFβ is a potent immunosuppressive cytokine, as it stimulates T regulatory cell (Tregs), inhibits NK cells, blocks the activation of T cell receptor (TCR), and polarizes tumor-associated macrophages (TAMs) and neutrophils to become M2-like activated macrophages and N2-activated neutrophils (49–51). This evidence concerns the gene TGFB1 and neoplasm.