More critically, this paper, for the initial time, elaborates that IFN-γ modulates the expression of ANGPT2 and Tie2 via the AKT-FOXO1 and JAK1/2-STAT1 pathways, thereby providing direct evidence for the normalization of tumor vascular structures regulated by IFN-γ in immunotherapy. This evidence concerns the gene ANGPT2 and neoplasm.