RBM15 also modulates procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (PLOD3), enhancing tumor-infiltrating CD4+ T cell abundance in esophageal squamous cell carcinoma (ESCC), correlating with favorable prognosis in ESCC4. The gene discussed is RBM15; the disease is esophageal squamous cell carcinoma.