Of note, expression of complement factor and complement receptors including C5aR1 has also been demonstrated on skin stromal cells such as fibroblasts and keratinocytes (30, 31), suggesting that the complement system contributes to EBA pathogenesis not only by the recruitment and activation of immune cells but fuels the immune-stromal crosstalk. The gene discussed is C5AR1; the disease is acquired epidermolysis bullosa.