Considering emerging data showing a critical role for C3aR and C5aR1 in the regulation of the B cell response in germinal centers (40) including T follicular helper cell differentiation (41) and class-switch recombination (42), AP and C5 targeting may also suppress the generation of COL7-specific AAbs, which should be assessed experimentally in the immunization-induced model of EBA (7) in the future. This evidence concerns the gene DHCR7-DT and acquired epidermolysis bullosa.