Recent findings have indicated an increase in CX3CR1-expressing myeloid DCs in mice subjected to a MCD diet, which led to heightened TNF-α production; conversely, blockade of CX3CR1 resulted in amelioration of steatohepatitis in mice, implicating a disease-promoting role for myeloid DCs in MASLD (84). Here, CX3CR1 is linked to metabolic dysfunction-associated steatotic liver disease.