NOP2 and lung cancer: NSUN2 upregulates the m5C modification of NRF2, with YBX1 binding to the m5C-modified NRF2 to maintain its transcript stability, thereby promoting the proliferation, migration, and ferroptosis resistance of NSCLC cells (87).The expression level of NOP2 is abnormally elevated in lung cancer, and its increased expression enhances the migratory and invasive abilities of lung cancer cells, as well as the growth and metastasis of transplanted tumors.