Notably, high USP13 expression in glioma stem cells stabilizes c-Myc, while its depletion enhances c-Myc ubiquitination and degradation, effectively inhibiting tumor growth; conversely, overexpression of FBXL14 promotes c-Myc degradation, leading to stem cell differentiation and further tumor suppression (277). This evidence concerns the gene USP13 and glioma.