24SOHC induces LXR-mediated adaptive responses; enhanced ABCG1 expression protects against 7KC-induced cytotoxicity; ABCA1 plays a less critical role in NB.24(S)-hydroxycholesterol upregulates ApoE, ABCA1, and ABCG1 in astrocytes; NR Modulators inhibit mTOR signaling via DDIT4 in OS. The gene discussed is DDIT4; the disease is neuroblastoma.