She later developed chronic enteropathy, pustular eczema, pan-sinusitis, chronic cough, and generalized lymphadenopathy until she was referred for immunological investigation and diagnosed with common variable immunodeficiency (CVID) at age 13 years when she presented with lymphoid interstitial pneumonia and bronchiectasis [IgG, 1.3 g/L; IgA, <0.1 g/L; IgM, <0.22 g/L; white blood cells (WBC), 9,200/μL; lymphocytes, 2,690/μL; CD3+ T cells, 58.4%; CD4+ helper T cells, 16.6%; CD8+ cytotoxic T cells, 30.8%; and CD19+ B cells, 4%), and intravenous Ig (IVIg) replacement was commenced. This evidence concerns the gene CD4 and common variable immunodeficiency.