Dexamethasone causes insulin resistance and hyperlipidemia leading to cellular lipotoxicity and glucotoxicity responsible for the overproduction of free radicals and therefore a weakening of antioxidant enzymes (CAT, SOD, GSH) in tissues (Ellah et al. 2017; Keeney et al. 1993). The gene discussed is SOD1; the disease is hyperlipidemia.