We observed that T2D-causing top-ranked six HKPs (UBE3C, ACAT1, HSPA9, ALDH4A1, LRPPRC, and RDX) and Mpox-causing top-ranked four HKPs (CDH1, PTPRC, IGF1, and PDGFRB) does not belong to cHKG set (Fig. S1). The gene discussed is IGF1; the disease is type 2 diabetes mellitus.