These results suggest that the oxidative stress-related hub genes CD44, ITGB2, MICB, and RAC2 may play significant roles in both glomerular and tubulointerstitial tissues in ANCA-associated vasculitis, while VCAM1 and VEGFA exhibit distinct tubulointerstitial tissue specificity. Here, MICB is linked to anti-neutrophil cytoplasmic antibody-associated vasculitis.