The ECM, integral to OC development and progression, comprises collagen fibers for strength, proteoglycans for cell shelter, and adhesive glycoproteins (like laminin and fibronectin) that connect collagen and proteoglycans to cell receptors (e.g., integrins, hyaluronic acid receptors) [323].The ECM component supports tumor development through providing proliferative signals, facilitating evasion of tumor growth inhibitors and apoptosis, enhancing replicative immortalization, inducing neovascularization and promoting tumor cell invasion and metastasis [324]. This evidence concerns the gene LAMB2 and neoplasm.