The results showed that the levels of CD4 memory T cells, common lymphoid progenitors (CLPs), CD4 + T helper 2 cells (Th2 cells) were notably increased, but the levels of CD4 effector memory T cells, endothelial cells, cancer associated fibroblasts (CAFs), M1 macrophages and NK T cells were significantly reduced in the high-NOP58 groups, compared to the low-NOP58 group (Fig. 4C). Here, CD4 is linked to cancer.