Among these pathways, five tumor development-related pathways including cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, MAPK signaling pathway, NF-kappa B signaling pathway and NOD-like receptor signaling pathway, were notably activated in the high-NOP58 group, compared to the low-NOP58 group (Fig. 5E). This evidence concerns the gene SOAT1 and neoplasm.