The concentration and protein expression levels of IL6 were significantly upregulated in HFpEF DM patients compared to HFpEF non-DM patients (Fig. 2A, B) and clearly in line with enhanced fluorescence intensity shown by immunohistochemistry staining in HFpEF DM patients compared to HFpEF non-DM patients (Fig. 2C). The gene discussed is IL6; the disease is diabetes mellitus.