Elevated urinary biomarkers IGFBP-7 and TIMP-2 further reflect renal tubular damage, consistent with their role as markers of acute kidney injury [2].Urinary biomarkers IGFBP-7 and TIMP-2 showed strong correlations with renal dysfunction (negative correlations with eGFR and albumin, positive correlations with creatinine) and disease progression (positive correlations with plasma cell percentage and LDH). This evidence concerns the gene TIMP2 and acute kidney injury.