MM patients exhibited renal dysfunction (low eGFR, high creatinine), hypoalbuminemia, elevated β2-microglobulin, high LDH, increased plasma cell percentage, and elevated serum amylase, along with elevated urinary biomarkers IGFBP-7 and TIMP-2, reflecting systemic and renal involvement. Here, IGFBP7 is linked to Abnormal renal physiology.