MM patients exhibited renal dysfunction (low eGFR, high creatinine), hypoalbuminemia, elevated β2-microglobulin, high LDH, increased plasma cell percentage, and elevated serum amylase, along with elevated urinary biomarkers IGFBP-7 and TIMP-2, reflecting systemic and renal involvement. This evidence concerns the gene HLA-G and Hypoalbuminemia.