ADORA2A and obesity due to melanocortin 4 receptor deficiency: Additionally, studies have shown that A2AR agonists, such as CGS21680 or PSB-0777, activate lipolysis, increase energy expenditure and oxygen consumption, improve glucose tolerance, prevent diet-induced obesity, and ultimately induce WAT browning (DeOliveira et al. 2017; Tozzi and Novak 2017; Mannino et al. 2021), reinforcing A2AR's role in adipose remodeling.