The nuclear factor erythroid 2-related factor 2 (NFE2L2 or NRF2) transcription factor is constitutively activated in many cancers and promotes a specific gene expression program involved in cellular detoxification, redox buffering, and metabolic rewiring (Cancer Genome Atlas Research, 2012; Cancer Genome Atlas Research et al, 2017; DeNicola et al, 2011; Rojo de la Vega et al, 2018). The gene discussed is NFE2L2; the disease is cancer.