Here, to assess the significance of those mutations on the risk of stroke in consideration of confounding factors such as hypertension, smoking status, diabetes mellitus, and sex, we conducted this comparative study on the potential relationship between the rs16944 T/C mutation in the IL-1β gene and the rs1800896 G/A in the IL-10 gene and the probabilities of ischemic stroke in the Egyptian population. The gene discussed is IL1B; the disease is stroke disorder.