The data of Reynolds et al. showed that the expression level of TNFSF12 (or TWEAK) in keratinocytes in psoriasis lesions was positively correlated with the expression of TNFRSF12A (or Fn14) (R = 0.0077, P = 0.082), which was consistent with the results of our previous study [19], while TWEAK was positively correlated with LCN2 but the transcripts demonstrating Spearman correlation was not significant, and Fn14 was negatively correlated with the expression level of LCN2 (R < 0.6, P < 2.1 3 10–344, 43/16,343 assessed genes). The gene discussed is LCN2; the disease is psoriasis.