The observed trend of high leukemic cell CLEVER-1 association with low HLA-DR expression and lymphocyte abundance in the BM, is in line with the immunosuppressive role of tumor-associated macrophage CLEVER-1 in solid tumors7,9,12 but requires further studies to validate the functional relevance of this association in myeloid malignancies. The gene discussed is STAB1; the disease is myeloid neoplasm.