Hence, CLEVER-1 deficient mice show increased frequency of tumor associated macrophages with high major histocompatibility complex (MHC) II protein expression9,10 These changes align with macrophage reprogramming and innate immunity activation, leading to release of other proinflammatory cytokines (e.g., interferon gamma (IFNγ) and activation of adaptive immune system (T cells)11,12. This evidence concerns the gene IFNG and neoplasm.