The deletion of ETS1 in HUVEC effectively inhibited the upregulations of VCAM-1, E-selectin, PAI-1, and TF induced by LPS in both protein and mRNA levels (Fig. 7B, C; Supplementary Fig. 3C–J), suggesting the regulatory importance of ETS1 in EC activation during sepsis. Here, SERPINE1 is linked to Sepsis.