MET and cancer: However, as a type of proto-oncogene, abnormal activation of c-MET can promote the development and progression of multiple cancers such as liver [14], lung [15], colon [16], breast [17], pancreatic [18], ovarian [19], prostate [20], and gastric carcinomas [21] by stimulating the PI3K/AKT [22], Ras/MAPK [23], JAK/STAT [24], Wnt/β-catenin [25], and other signaling pathways.