FBLN5 and neoplasm: High FBLN5 expression was associated with an increased risk of overall and disease-specific mortality, after adjusting for confounding variables such as age, sex, tumor location, tumor size and TNM stage The adjusted HR for overall mortality was 1.515 (95% confidence interval (CI) 1.019–2.251, P = 0.040) and for disease-specific mortality was 1.673 (95% CI 1.013–2.762, P = 0.044) (Tables 3 and 4).